2,915 research outputs found
The Role of Column Density in the Formation of Stars and Black Holes
The stellar mass in disk galaxies scales approximately with the fourth power
of the rotation velocity, and the masses of the central black holes in galactic
nuclei scale approximately with the fourth power of the bulge velocity
dispersion. It is shown here that these relations can be accounted for if, in a
forming galaxy with an isothermal mass distribution, gas with a column density
above about 8 Msun/pc^2 goes into stars while gas with a column density above
about 2 g/cm^2 (10^4 Msun/pc^2) goes into a central black hole. The lower
critical value is close to the column density of about 10 Msun/pc^2 at which
atomic gas becomes molecular, and the upper value agrees approximately with the
column density of about 1 g/cm^2 at which the gas becomes optically thick to
its cooling radiation. These results are plausible because molecule formation
is evidently necessary for star formation, and because the onset of a high
optical depth in a galactic nucleus may suppress continuing star formation and
favour the growth of a central black hole.Comment: Accepted by Nature Physic
The Formation of the First Low-Mass Stars From Gas With Low Carbon and Oxygen Abundances
The first stars in the Universe are predicted to have been much more massive
than the Sun. Gravitational condensation accompanied by cooling of the
primordial gas due to molecular hydrogen, yields a minimum fragmentation scale
of a few hundred solar masses. Numerical simulations indicate that once a gas
clump acquires this mass, it undergoes a slow, quasi-hydrostatic contraction
without further fragmentation. Here we show that as soon as the primordial gas
- left over from the Big Bang - is enriched by supernovae to a carbon or oxygen
abundance as small as ~0.01-0.1% of that found in the Sun, cooling by
singly-ionized carbon or neutral oxygen can lead to the formation of low-mass
stars. This mechanism naturally accommodates the discovery of solar mass stars
with unusually low (10^{-5.3} of the solar value) iron abundance but with a
high (10^{-1.3} solar) carbon abundance. The minimum stellar mass at early
epochs is partially regulated by the temperature of the cosmic microwave
background. The derived critical abundances can be used to identify those
metal-poor stars in our Milky Way galaxy with elemental patterns imprinted by
the first supernovae.Comment: 14 pages, 2 figures (appeared today in Nature
Increasing the frequency of hand washing by healthcare workers does not lead to commensurate reductions in staphylococcal infection in a hospital ward
Hand hygiene is generally considered to be the most important measure that can be applied to prevent the spread of healthcare-associated infection (HAI). Continuous emphasis on this intervention has lead to the widespread opinion that HAI rates can be greatly reduced by increased hand hygiene compliance alone. However, this assumes that the effectiveness of hand hygiene is not constrained by other factors and that improved compliance in excess of a given level, in itself, will result in a commensurate reduction in the incidence of HAI. However, several researchers have found the law of diminishing returns to apply to hand hygiene, with the greatest benefits occurring in the first 20% or so of compliance, and others have demonstrated that poor cohorting of nursing staff profoundly influences the effectiveness of hand hygiene measures. Collectively, these findings raise intriguing questions about the extent to which increasing compliance alone can further reduce rates of HAI.
In order to investigate these issues further, we constructed a deterministic Ross-Macdonald model and applied it to a hypothetical general medical ward. In this model the transmission of staphylococcal infection was assumed to occur after contact with the transiently colonized hands of HCWs, who, in turn, acquire contamination only by touching colonized patients. The aim of the study was to evaluate the impact of imperfect hand cleansing on the transmission of staphylococcal infection and to identify, whether there is a limit, above which further hand hygiene compliance is unlikely to be of benefit.
The model demonstrated that if transmission is solely via the hands of HCWs, it should, under most circumstances, be possible to prevent outbreaks of staphylococcal infection from occurring at a hand cleansing frequencies <50%, even with imperfect hand hygiene. The analysis also indicated that the relationship between hand cleansing efficacy and frequency is not linear - as efficacy decreases, so the hand cleansing frequency required to ensure R0<1 increases disproportionately.
Although our study confirmed hand hygiene to be an effective control measure, it demonstrated that the law of diminishing returns applies, with the greatest benefit derived from the first 20% or so of compliance. Indeed, our analysis suggests that there is little benefit to be accrued from very high levels of hand cleansing and that in most situations compliance >40% should be enough to prevent outbreaks of staphylococcal infection occurring, if transmission is solely via the hands of HCWs. Furthermore we identified a non-linear relationship between hand cleansing efficacy and frequency, suggesting that it is important to maximise the efficacy of the hand cleansing process
Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting
We present an analytical method to quantify clustering in super-resolution
localization images of static surfaces in two dimensions. The method also
describes how over-counting of labeled molecules contributes to apparent
self-clustering and how the effective lateral resolution of an image can be
determined. This treatment applies to clustering of proteins and lipids in
membranes, where there is significant interest in using super-resolution
localization techniques to probe membrane heterogeneity. When images are
quantified using pair correlation functions, the magnitude of apparent
clustering due to over-counting will vary inversely with the surface density of
labeled molecules and does not depend on the number of times an average
molecule is counted. Over-counting does not yield apparent co-clustering in
double label experiments when pair cross-correlation functions are measured. We
apply our analytical method to quantify the distribution of the IgE receptor
(Fc{\epsilon}RI) on the plasma membranes of chemically fixed RBL-2H3 mast cells
from images acquired using stochastic optical reconstruction microscopy (STORM)
and scanning electron microscopy (SEM). We find that apparent clustering of
labeled IgE bound to Fc{\epsilon}RI detected with both methods arises from
over-counting of individual complexes. Thus our results indicate that these
receptors are randomly distributed within the resolution and sensitivity limits
of these experiments.Comment: 22 pages, 5 figure
The origin of dust in galaxies revisited: the mechanism determining dust content
The origin of cosmic dust is a fundamental issue in planetary science. This
paper revisits the origin of dust in galaxies, in particular, in the Milky Way,
by using a chemical evolution model of a galaxy composed of stars, interstellar
medium, metals (elements heavier than helium), and dust. We start from a review
of time-evolutionary equations of the four components, and then, we present
simple recipes for the stellar remnant mass and yields of metal and dust based
on models of stellar nucleosynthesis and dust formation. After calibrating some
model parameters with the data from the solar neighborhood, we have confirmed a
shortage of the stellar dust production rate relative to the dust destruction
rate by supernovae if the destruction efficiency suggested by theoretical works
is correct. If the dust mass growth by material accretion in molecular clouds
is active, the observed dust amount in the solar neighborhood is reproduced. We
present a clear analytic explanation of the mechanism for determining dust
content in galaxies after the activation of accretion growth: a balance between
accretion growth and supernova destruction. Thus, the dust content is
independent of the uncertainty of the stellar dust yield after the growth
activation. The timing of the activation is determined by a critical metal mass
fraction which depends on the growth and destruction efficiencies. The solar
system formation seems to have occurred well after the activation and plenty of
dust would have existed in the proto-solar nebula.Comment: 12 pages, 11 figure
The ethics of uncertainty for data subjects
Modern health data practices come with many practical uncertainties. In this paper, I argue that data subjects’ trust in the institutions and organizations that control their data, and their ability to know their own moral obligations in relation to their data, are undermined by significant uncertainties regarding the what, how, and who of mass data collection and analysis. I conclude by considering how proposals for managing situations of high uncertainty might be applied to this problem. These emphasize increasing organizational flexibility, knowledge, and capacity, and reducing hazard
A curriculum to teach medical students to care for people with disabilities: development and initial implementation
<p>Abstract</p> <p>Background</p> <p>Lack of knowledge and skills, and negative attitudes towards patients with disabilities, may adversely affect the services available to this group and negatively affect their health outcomes. The objective of this paper is to describe the development and initial implementation of a curriculum for teaching medical students to care for patients with disabilities.</p> <p>Methods</p> <p>We followed the six-step approach for developing curricula for medical education: general needs assessment, specific needs assessment, defining goals and objectives, determining the educational strategies, planning the implementation, and developing an evaluation plan.</p> <p>Results</p> <p>The curriculum has well defined goals and objectives covering knowledge, attitudes and skills. It employs both traditional and non-traditional teaching strategies. The implementation is planned over the four-year medical school curriculum in collaboration with a number of academic departments and specialized community-based agencies. The curriculum evaluation includes an attitudinal survey which is administered using a controlled design (pre- and post- exposure to the curriculum). The initial implementation of the curriculum has been very successful.</p> <p>Conclusion</p> <p>We have developed a longitudinal curriculum to teach medical students to care for people with disabilities. A rigorous evaluation of the impact of the curriculum is needed.</p
Microfluidic systems for the analysis of the viscoelastic fluid flow phenomena in porous media
In this study, two microfluidic devices are proposed as simplified 1-D microfluidic analogues of a porous medium. The objectives are twofold: firstly to assess the usefulness of the microchannels to mimic the porous medium in a controlled and simplified manner, and secondly to obtain a better insight about the flow characteristics of viscoelastic fluids flowing through a packed bed. For these purposes, flow visualizations and pressure drop measurements are conducted with Newtonian and viscoelastic fluids. The 1-D microfluidic analogues of porous medium consisted of microchannels with a sequence of contractions/ expansions disposed in symmetric and asymmetric arrangements. The real porous medium is in reality, a complex combination of the two arrangements of particles simulated with the microchannels, which can be considered as limiting ideal configurations. The results show that both configurations are able to mimic well the pressure drop variation with flow rate for Newtonian fluids. However, due to the intrinsic differences in the deformation rate profiles associated with each microgeometry, the symmetric configuration is more suitable for studying the flow of viscoelastic fluids at low De values, while the asymmetric configuration provides better results at high De values. In this way, both microgeometries seem to be complementary and could be interesting tools to obtain a better insight about the flow of viscoelastic fluids through a porous medium. Such model systems could be very interesting to use in polymer-flood processes for enhanced oil recovery, for instance, as a tool for selecting the most suitable viscoelastic fluid to be used in a specific formation. The selection of the fluid properties of a detergent for cleaning oil contaminated soil, sand, and in general, any porous material, is another possible application
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